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3 per 1000 person-years vs 19.4 per 1000 person-years, P less then .0001) was attributable to longer duration of medical follow-up.In this study, allopurinol use was not associated with decreased diabetes incidence. Prospective studies may further elucidate the relationship between hyperuricemia, gout, xanthine oxidase activity, and diabetes, and the potential impact of gout treatments on diabetes incidence. Total knee arthroplasty (TKA) is known to be a painful orthopedic procedure and moderate to severe pain is common, especially imme