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[18F]1 exhibited stable uptake and retention in HepG2 tumor xenografts (~3 %ID/g) in vivo, but poor clearance from blood and other normal tissues, yielding low tumor-to-background ratios ( less then 2) at 2 h post injection. Our results suggest that [18F]1 has suboptimal characteristics for in vivo evaluation as a PET tracer for MDM2, but warrant radiolabeling and assessment of the other fluorinated analogues synthesized in this work, 2 and 3, and potentially other molecular scaffolds for developing MDM2 targeted radiotracers.The fracture resistanc

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Such findings will be useful for the timely diagnosis and subsequent treatment planning of IgG4-RDHP.PURPOSE To investigate the ability of three-dimensional double-echo steady-state with water excitation sequence (3D-DESS-WE) in detecting the greater occipital nerve (GON) and the lesser occipital nerve (LON). MATERIALS AND METHODS We retrospectively reviewed 66 consecutive patients who underwent magnetic resonance imaging, including 3D-DESS-WE. Two readers evaluated the detectability [0 (poor) to 3 (excellent)] and thickness of the GON