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Mechanics plays a crucial role at the micro- and nanoscales, from the generation of nanostructures towards the properties of nanocomposite products while the production and design of devices, structures, detectors, actuators, fluidics, and much more. This Unique Issue aims to bring together high-quality papers that advance the field of micro- and nanostructures and methods through the use of contemporary computational and analytical practices, in conjunction with experimental practices, f