https://www.selleckchem.com/pr....oducts/iberdomide.ht
There is increasing evidence that inducing neuronal mitophagy can be used as a therapeutic intervention for Alzheimer's disease. Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator. UMI-77 is an established BH3-mimetic for MCL-1 and was developed to induce apoptosis in cancer cells. We found that at sub-lethal doses, UMI-77 potently induces mitophagy, independent of apoptosis. Our mechanistic studies discovered that MCL-1 is a mitophagy receptor and directly b

https://www.bunkbedsstore.uk/c....ategories/single-bun
Bunk Bed Mattresses For Single Sleepers Many bunk beds can be divided into single beds. This is beneficial when children stop sharing bedrooms as they age. Single bunk beds are available in sizes twin over twin, full and twin XL. They can accommodate most types of bed frames, and don't require box springs. Durability Bunk beds are an excellent way to increase the space available in a room. The built-in structure could be a challenge for some sleepers. This is why it's important to choose a mattress that is robust and able to su