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PEEP 15 cmH2O; p = 0.31). However, both PaCO2 and Cstat worsened (PaCO2 72.5 ± 7.1 vs. 75.1 ± 9.0 mmHg; p less then 0.01. Cstat 17.5 ± 3.5 vs. 16.6 ± 3.9 ml/cmH2O; p = 0.05). Only four patients (20%) were considered lung recruitable. Individually titrated PEEP was higher than the baseline PEEP (8.0 ± 2.1 cmH2O vs. 5 cmH2O, p less then 0.001). After 18-20 h of prone positioning, investigated parameters were significantly improved compared to the baseline (PaO2 82.4 ± 15.5 mmHg. PaCO2 67.2 ± 6.4 mmHg. Cstat 20.6 ± 4.4 ml/cmH2O. All p le