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The levels of MUC5AC and MUC5B in lung structure were additionally suppressed. These results reveal that andrographolide sulfate remarkably eased pneumonia induced by poly IC in mice. Moreover, andrographolide sulfonate markedly inhibited the activation of nuclear factor-κB (NF-κ. Taken collectively, we demonstrated that andrographolide sulfonate ameliorated poly I C-induced pneumonia in mice, recommending the possible use of andrographolide sulfonate for virus-induced pn