https://www.selleckchem.com/pr....oducts/bay-87-2243.h
The population pharmacokinetic parameters (CL and V) according to the final model were 3.16 (95%CI 2.83, 3.4 L/h and 60.71 (95%CI 53.15, 67.46). The mean absolute prediction error for external validation by the final model was 12.61% (95CI 8.77%, 16.45%). Finally, the prediction accuracy of 90.21% of the patients' detected trough concentrations that were distributed in the target range of 10-20 μg/ml after dosing adjustment was found to be adequate. There is significant heterogeneity in the CL and V of vancomycin in ICU patients.
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