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The Best Automatic Vacuums There are numerous options to choose from, whether you want a vacuum cleaner that can mop or one that will store floor maps. Or one that will automatically return to its charging station at end of each cleaning session. The top robotic vacuums provide high-end features for a reasonable price. Look for models that have a long battery life as well as large dust bins and navigation tools that are able to avoid obstacles. Many models connect to digital voice assistants to provide hands-free experiences and can stop, recharge and restart whe

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We previously described that the immediate early (IE) IE180 protein of PRV can down-regulate the transactivation of the ICP4 promoter of HSV-1, and that the d120 virus (an ICP4-deficient HSV-1 strain) can partially replicate its viral DNA in the presence of the IE180 protein. Herein, we demonstrate that this partial complementation of d120 by IE180 is sufficient for transcription of β, γ1 and γ2 products such as DNA pol, VP16 and gC, respectively. However, expression levels are low for VP16 and even lower for the gC, such that IE180 is