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Hemorrhagic shock and encephalopathy syndrome (HSES) is a devastating disease and has an uncertain pathogenesis. The aim of this study was to predict neurological outcomes for HSES using magnetic resonance imaging (MRI) findings at neurological onset and elucidate the pathophysiology of HSES in the acute phase from serial MRI changes. We analyzed the MRI findings of 13 patients who underwent an initial MRI within 24h of neurological onset. According to neurological prognosis, seven patients were included in the severe group and six in