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ccination, is necessary to effectively decrease household transmission.Universities have turned to SARS-CoV-2 models to examine campus reopening strategies 1-9 . While these studies have explored a variety of modeling techniques, all have relied on simulated data. Here, we use an empirical proximity network of college freshmen 10 , ascertained using smartphone Bluetooth, to simulate the spread of the virus. We investigate the role of testing, isolation, mask wearing, and social distancing in the presence of implementation challenges