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According to pathway analysis, there were 3 and 5 metabolic pathways remarkably perturbed in MetS and MetS HUA group respectively. Taken together, we identified disordered metabolites and related pathways for both MetS and MetS HUA patients, and found a more severe metabolic disorder in MetS patients who has a higher serum uric acid. Our study provides biochemical insights into the metabolic alteration for the progress of MetS. Taken together, we identified disordered metabolites and related pathways for both MetS and