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© 2020 Her Majesty the Queen in Right of Canada Lipids © 2020 AOCS.As understanding the nature of brain networks through dynamic functional connectivity (dFC) estimation is of paramount significant, the introduction and revision of blood-oxygen-level dependent (BOLD) signal simulation methods in brain regions and dFC estimation methods have gained significant ground in recent years. Based on the observation of BOLD signals with multivariate nonnormal distribution in functional magnetic resonance imaging (fMRI) images, we first prop