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BACKGROUND Relapsed ventricular assist device (VAD) -specific infections are associated with high morbidity, mortality, and hospital costs. A new combination of cold atmospheric plasma and special dressing technique with negative pressure wound therapy with an additional underlay of carbon cloth and hypochlorite rinsing solutions has been developed and reported in this study. METHODS Between January 2016 and January 2018, nine patients with relapsed infected driveline and/or pump pocket infection were treated with this new combined strateg