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First Line Treatment For ADHD in Adults Some people with ADHD are able to use medications to manage their symptoms. Stimulants such as methylphenidate or amphetamine are used to increase brain activity in the areas that regulate behavior and attention. Other medications, such as the non-stimulant drug atomoxetine and some antidepressants work differently, yet are effective. Regular visits to the GP are recommended for those who take medication. Th