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In your study cohort, 129 had a pathogenic or most likely pathogenic CREBBP variation and 5 had a variant of uncertain relevance (VUS) which warranted familial studies. 147 of this remaining probands had been also screened for EP300 and an additional 16 pathogenic or likely pathogenic variants had been identified, plus one VUS. Therefore, this evaluation has provided a molecular analysis in at the least 145 individuals with RSTS (37%) and identified a wide range of variants (n = 133) of which 103 had been

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iated with increased odds of PICU mortality, independent of illness severity. Longer duration of exposure to HFNC/NIPPV prior to IMV is associated with increased mortality in HCT patients. In IC pediatric patients, preintubation exposure to HFNC and/or NIPPV is associated with increased odds of PICU mortality, independent of illness severity. Longer duration of exposure to HFNC/NIPPV prior to IMV is associated with increased mortality in HCT patients. High physical exertion during healthcare work is a documented r