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t the nail bed effectively, and also has a significant effect on preventing postoperative nail deformity. To explore the suitable division of male genitalia subunits and the effectiveness of large-area perineum defect repair under its guidance. According to the anatomical and functional characteristics of male genitalia, the subunit division scheme was proposed area Ⅰ, glans penis; area Ⅱ, body of penis; area Ⅲ, scrotum; area Ⅳ, scrotum. Between April 2017 and July 2019, 12 patients with large genitalia defects were treated, with an