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Spontaneous splenic rupture is a known, but rare and possibly fatal, complication of different infectious diseases. We present a case of a 38-year-old male patient who presented with fever, icterus and spontaneous splenic rupture after a visit to Vietnam and discuss the differential diagnosis of splenic rupture in ill returned travellers. Spontaneous splenic rupture is a rare complication of several tropical diseases, including infection.Atypical presentations of infection should always be considered in febrile ill returned travellers.