https://www.selleckchem.com/pr....oducts/imidazole-ket
This intermediate is identical to that found in the catalytic cycle of cystathionine γ-synthase (Met, which is a homologous enzyme from the trans-sulfurylation pathway. By comparing the TmMetY and MetB structures, we have identified Arg270 as a critical determinant of specificity. It helps to wall off the active site of TmMetY, disfavoring the binding of the first MetB substrate, O-succinylhomoserine. It also ensures a strict specificity for bisulfide as the second substrate of MetY by occluding the larger MetB substr
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