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5 mg kg ). In the HSD rat group, all Mayan plant foods (10 mg kg ) demonstrated antihyperglycemic activity statistically equal (P ≤ 0.05) to control acarbose. However, Brassica oleracea and R. sativus registered the highest antihyperglycemic activity. Bixa orellana and P. guajava (5 mg kg ) showed similar hypoglycemic activity (P ≤ 0.05) to glibenclamide (0.5 mg kg ) but was not significant (P ≤ 0.05) compared to insulin (5 UI kg ). The present study provides valuable evidence on the possible health benefits of Mayan plant foods. The