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Microplastics are an emerging contaminant of high environmental concern due to their widespread distribution and availability to aquatic organisms. Filter-feeding organisms like bivalves have been identified as particularly susceptible to microplastics, and because of this, it has been suggested bivalves could be useful bioindicators of microplastic pollution in ecosystems. We sampled resident mussels and clams from five sites within San Francisco Bay for microplastics and other anthropogenic microparticles. Cages of depurated mussels (