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Considerable decrease in TNF-α and TGF-β with concomitant increase in IL-10 levels were observed. Furthermore, the phrase of HIF-1α, VEGF and γH2AX declined. SIGNIFICANCE 2ME2 is a promising radioprotectant with less expected complications. Is designed to unravel the root process of hepatic swelling during type 2 diabetes (T2DM), we established the diabetic rat design by feeding with high fructose diet for twenty days and learned the participation of infla