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40; 95% confidence interval [CI], 1.16-1.76; p=0.004). Both the UofA (OR1.73; 95% CI, 1.23-2.43; p=0.002) and UPenn (OR1.27; 95% CI, 1.02-1.58; p=0.035) populations showed a significant positive association between the number of combined risk alleles of GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP and risk for CRS. Carriers of the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP are at increased susceptibility for CRS. These data suggest that therapeutic approaches to target aberrant responses to RV infection may play a role in the treatment o
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