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4. This work contributes to more effective control strategies for PM2.5 in resource-dependent areas. To investigate the effects of mandible advanced device (MAD) therapy for obstructive sleep apnea-hypopnea syndrome (OSAHS) on nitric oxide (NO) release and changes in pulmonary artery pressure and structure. Thirty male New Zealand white rabbits were randomly divided into OSAHS, MAD, and control groups (n=10 per group). The soft palate of rabbits in the OSAHS and MAD groups was injected with hydrophilic polyacrylamide gel to induce OSAHS.