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The role of Renin-Angiotensin-System (RAS) in the pathogenesis of preeclampsia and eclampsia is still unclear. Our aim was to investigate plasma angiotensin II concentration [Ang II] in women with normotensive pregnancies (NP, n = 22) and severe preeclampsia in use of magnesium sulfate (SPE, n = 29). Despite no difference between the groups (SPE 47.8 pg/ml vs NP 39.7 pg/ml, p = 0.195), lower maternal age (p = 0.007) and primigravida (p = 0.028) were associated with lower [Ang II]. Plasma [Ang II] increased over the 24 h of magnesium sul