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In this cross-sectional study, we examine disparities in physical activity (PA) rates, a determinant of obesity risk, by exploring the impact of household economic hardship, social support, and family structure on adolescent physical activity levels. We assess whether these factors have a different impact on PA stratified by parental nativity status (Hispanic adolescents of foreign- and native-born caregivers compared with whites). The sample included 1927 white and Hispanic 15-year-olds of foreign-born (outside of USA) and native US-bor