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Collectively, the results demonstrate that UA and 4-methoxycoumarin have potential as eco-friendly and safe strategies to control TMV in the future.Equilibrium in the immune system is maintained by a balance between activation, which generates effector and memory cells, and suppression, which is mediated mainly by regulatory T cells. Understanding this balance and how to exploit it therapeutically is one of the dominant themes of modern immunology. The cytokine IL-2 was discovered as a growth factor for T cells and thus a k