https://www.selleckchem.com/pr....oducts/epz004777.htm
Thyroid hormones (THs) are crucial for maturation and functioning of mammalian CNS. THs "classical" signaling involves nuclear receptors binding but alsotheir non genomic actions, as rapid modulators of cell activity, are widely recognized. Since THs imbalance affects cognition and the cholinergic system is deeply involved in learning and memory processes we have studied THs effects at the level of the nicotinic acetylcholine receptors (nAchR). We used the patch-clamp technique to analyze T3 and T4 modulation of nicotine (NIC)-mediate