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The HESA will have broad applicability for identifying genes associated with exoproteome production in a range of microorganisms. Perforation of the lingual plate in the apical region of mandibular third molars will increase the risk of aberration and migration of the root tip and the risk of lingual nerve injury. The aim of this study was to analyze anatomical information, including relationships between the apical region of horizontally impacted mandibular third molars and lingual plates, in young Japanese. Japanese patients, with hori