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The Most Effective ADHD Medication For Adults Stimulants are the first-choice medication for adults with ADHD. They help adjust levels of two chemical messengers within the brain that regulate attention. The most effective medication for adhd for adults is Strattera (atomoxetine). It is available as capsules that can be taken with food or without. It works well for most people. It lasts longer than stimulants with a shorter duration of action, such as amphetamine or methylphenidate. 1
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