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ADHD Treatment For Adults - Stimulant Medication Stimulant medicines like methylphenidate or dextroamphetamine have been regarded as the first-line therapy for adult ADHD. These medications balance and increase levels of brain chemicals, known as neurotransmitters. Non-stimulant medications like atomoxetine and antidepressants may be prescribed when stimulants are not appropriate for the patient because of other health issues or side effects. These medications are slower acting