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The two modules were further validated by log-rank test in the validation dataset GSE3494. Both of the two modules show significantly different with p-values less than 0.02. The identified two modules confirmed previous findings including importance of biological networks in breast cancer involved in hormone response and M-phase. Out of the top twenty hub genes in the two modules, fifteen genes were previously shown to be prognostic markers for breast cancer.In 1910, the Russian biologist Konstantin Sergejewitch Mereschkowsky (Конста

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