https://www.selleckchem.com/pr....oducts/sacituzumab-g
a) the stimulatory effects of GIP and GLP-1 differ markedly ISR potentiation increases linearly with GLP-1 over the whole dose range, while with GIP infusion it reaches a plateau at ~100 pmol/L GIP, with ISR potentiation of ~2 fold; b) ISR potentiation in T2D is reduced by ~50% for GIP and by ~40% for GLP-1; c) the literature search of GIP in NGT subjects confirmed the saturative effect on insulin secretion. We show that incretin potentiation of ISR is reduced in T2D, but not abolished, and that the lack of effects of phar
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