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Adult ADHD and Comorbid Disorders Many adults suffering from ADHD also have comorbid disorders, such as major depressive disorder (Kessler and colleagues, 2006). Many sufferers do not respond to medications for depression and may benefit from psychotherapy. Neurotransmitters are brain chemicals that regulate and increase levels of certain brain chemicals. Drugs that stimulate the brain such as methylphenidate or amphetamine are often prescribed. Medicines Many of the medications used to t