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With a median follow-up of 10 years (range 5-27, mean 11.4) comprising 3,042 person-years, six SPMs developed of which only one (papillary thyroid carcinoma) was within the radiation field (crude rate of 0.38% of irradiated breasts/chestwalls), diagnosed 17 years after RT. This corresponds to an incidence of 0.32/1000 woman-years. The Kaplan-Meier estimate of 20-year freedom from a radiation-induced SPM is 99.5%. Calculated dose exposure to the out-of-field SPMs ranged from 0.1-1Gy. No patient developed an in-field skin cancer or s

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tion between vitamin D and all its metabolites with ACS. Significantly, low 25(OH)D and 1,25(OH)2D predicted ACS, but vitamin D2 and D3 did not. Large randomized controlled trials are needed to verify the beneficial values of vitamin D supplementation in ACS patients.The burden and cost of heart failure management, primarily in the form of hospitalization in the setting of decompensated heart failure, continue to be some of the biggest clinical challenges in cardiovascular medicine. In recently published randomized controlled trials, inc