https://www.selleckchem.com/pr....oducts/LY2603618-IC-
Increased AEA signalling at vanilloid TRPV1 receptors impaired fear memory extinction. In contrast, inhibition of 2-AG hydrolysis promoted active over passive fear responses acutely via activation of cannabinoid (CB ) receptors. Measurement of AEA and 2-AG levels after extinction training revealed sex- and brain region-specific changes. We provide the first evidence that AEA and 2-AG signalling affect fear expression and extinction in females in opposite directions. These findings are relevant to future research on sex differenc

https://www.selleckchem.com/pr....oducts/s-adenosyl-l-
tween pain and psychosocial functioning in SCD.Type 1 diabetes (T1D) is an autoimmune disease resulting in the destruction of the insulin-producing pancreatic beta cells. Disease progression occurs along a trajectory from genetic risk, the development of islet autoantibodies, and autoreactive T cells ultimately progressing to clinical disease. Natural history studies and mechanistic studies linked to clinical trials have provided insight into the role of the immune system in disease pathogenesis. Here, we review our cu