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Hydrazide-hydrazones were synthesized from 4-substituted benzohydrazides and 2-/4- hydroxy-3,5-diiodobenzaldehydes. The substances had been investigated in vitro with regards to their potency to prevent AChE from electric eel and BuChE from equine serum making use of Ellman's technique. We calculated also physicochemical and structural parameters for CNS delivery. The types exhibited a moderate double inhibition with IC50 values which range from 15.1-140.5 and 35.5 to 170.5 μmol.L-1 for AChE and BuChE, co
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