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3 mV at a current density of 10 mA cm-2 . These crystals outperform those of commercial Pt and nanostructured catalysts. This work opens a new avenue for the development of high-efficiency catalysts with the strategy of topological engineering of excellent transitional catalytic materials. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.G protein-coupled receptors (GPCRs) transmit extracellular signals into cells by activating G protein- and β-arrestin-dependent pathways. Extracellular signal-regulated kinas