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81 (2.34-14.4, =0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR=3.45 (1.13-10.5, =0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations. Witnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose. W