https://www.selleckchem.com/pr....oducts/pf-07220060.h
Pathologic calcium (Ca2+) signaling linked to Alzheimer's disease (AD) involves the intracellular Ca2+ release channels/ryanodine receptors (RyRs). RyRs are macromolecular complexes where the protein-protein interactions between RyRs and several regulatory proteins impact the channel function. Pharmacological and genetic approaches link the destabilization of RyRs macromolecular complexes to several human pathologies including brain disorders. In this review we discuss our recent data demonstrating that enhanced neuronal RyR2-mediat
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