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NGS revealed TP53 as the most frequently mutated gene. The rate of HER2 positive cases and MSI-H cases were 9.5% (4/42) and 12.2% (5/41), respectively. Among these 42 cases, there was no molecular and clinicopathological differences according to the presence of tumor cells with clear cytoplasm. Enteroblastic marker-positive CRC could be grouped together as CAED regardless of clear cell cytoplasm. By this definition, the frequency of CAED is 4.0%, and it has a poorer prognosis than that for conventional CRCs. HER2 targeting therapy would