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Besides the known physiological uptake of 131I, literature describes various false-positive findings on 131I scans in benign lesions, inflammation, traumatic sites, and post-surgical sites to name a few. However, no study to the best of our knowledge has shown the false-positive uptake of 131I in a post-operative seroma at the post-surgical site.Known off-target interactions frequently cause predictable drug side-effects (e.g., β1-antagonists used for heart disease, risk β2-mediated bronchospasm). Computer-aided drug design would improve