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21±3.10 mm Hg in the PF latanoprost group and -7.02±3.17 mm Hg in the BAK latanoprost group, both 0.0001). There was no statistically significant diurnal IOP variation between the groups. In terms of tolerability, pruritus, burning/stinging, and sticky eye sensation, severity was significantly lower in the PF latanoprost group than in the BAK latanoprost group ( 0.05). PF latanoprost has at least similar efficacy in terms of IOP reduction and better tolerability compared with BAK latanoprost. PF latanoprost has at least