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ieties of applications requiring in vivo volumetric imaging over large length scales. The proposed mesoscopic scanning OPM allows using low NA objectives such that centimeter-level FOV volumetric imaging can be achieved. With the extended FOV, simple sample mounting protocol, and the versatility of changeable FOVs/resolutions, our system will be ready for the varieties of applications requiring in vivo volumetric imaging over large length scales. Multi-photon imaging of the cerebrovasculature provides rich data on the dynamics of