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We compared the secretome of p53-null AsPC-1 PDAC cells after ectopic over-expression of R175H-mutp53 or R273H-mutp53 to identify the differentially secreted proteins by mutant p53. By using high-resolution SWATH-MS technology, we found many differentially released proteins because of the two p53 mutants, 15 of which are common to both mutants. These types of secreted proteins are reported to advertise cancer development and epithelial-me