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Epizootics and hereditary diversity of USUV in numerous bird types as well as recognition regarding the virus in mosquitoes advise repeated USUV introductions into Europe with endemization in some countries. The zoonotic potential of USUV was reported in an increasing number of real human cases. Clinical instances of neuroinvasive disease and USUV fever, along with seroconversion in bloodstream donors were reported in European countries since 2009. While most USUV