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One of the remarkable abilities of humans is to focus the attention on a certain speaker in a multi-speaker environment that is known as the cocktail party effect. How the human brain solves this non-trivial task is a challenge that the scientific community has not yet found answers to. In recent years, progress has been made thanks to the development of system identification method based on least-squares (LS) that maps the variations between the cortical signals of a listener and the speech signals present in an auditory scene. Results f

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Despite having adequate solubility properties, bioequivalence (BE) studies performed on immediate release formulations containing BCS1/3 drugs occasionally fail. By systematically evaluating a set of 17 soluble drugs where unexpected BE failures have been reported and comparing to a set of 29 drugs where no such reports have been documented, a broad assessment of the risk factors leading to BE failure was performed. BE failures for BCS1/3 drugs were predominantly related to changes in Cmax rather than AUC. Cmax changes were typically m