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This can be among the first studies on circulating miR-21 as a possible biomarker of reaction to CRT in RC clients.Acute kidney injury (AKI), triggered primarily by ischemia-reperfusion, sepsis, or nephrotoxins (such as contrast medium), is identified by an abrupt decrease in kidney function and it is related to high morbidity and mortality. Despite years of efforts, the pathogenesis of AKI remains poorly recognized, and efficient treatments are lacking. MicroRNAs (miRNAs) tend to be little