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The design incorporated information including BSE prevalence, infectivity levels in the intestines, manufacturing batch dimensions, yield of heparin, decrease in infectivity by production process, while the dose-response commitment. RESULTS The design estimates a median threat of vCJD infection from a single intravenous dose (10 000 USP devices) of heparin created from US-sourced bovine intestines becoming 6.9 × 10-9 (2.5-97.fifth percentile 1.5 × 10-9 -4.3 × 10-8 ), a risk of 1 in 145 million, and 4.6