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Deleting the GAF domain from PtsP makes cells "blind" to the cellular nitrogen status. PTSNtr constitutes a switch through which carbon and nitrogen metabolism are rapidly, and reversibly, regulated by proteinprotein interactions. PTSNtr is widely conserved in proteobacteria, highlighting its global importance.Researchers and policy makers worldwide are interested in measuring the subjective well-being of populations. When users post on social media, they leave behind digital traces that reflect their thoughts and feelings. Aggregation