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Finding the Best Medication For ADHD The most commonly prescribed medication for ADHD is stimulants. They include amphetamines and methylphenidates. Short-acting stimulants start working in less than one hour and need to be taken several times per day. Long-acting stimulants last up to 16 hour and are taken every day. Your doctor may prescribe antidepressants or other types of medication "off-label" to treat ADHD symptoms. These are approved medications to treat other